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The CKD-EPI creatinine equation is based on the same four variables as the MDRD Study equation, but uses a 2-slope �spline� to model the relationship between estimated GFR and serum creatinine, and a different relationship for age, sex and race. The equation was reported to perform better and with less bias than the MDRD Study equation, especially in patients with higher GFR. This resulted in a reduced misclassification of CKD.

The CKD-EPI creatinine equation is:

Ann Intern Med. 2009; 150:604-612.