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The CKD-EPI creatinine equation is based on the same four variables as the MDRD Study equation, but uses a 2-slope “spline” to model the relationship between estimated GFR and serum creatinine, and a different
relationship for age, sex and race. The equation was reported to perform better and with less bias than the MDRD Study equation, especially in patients with higher GFR. This results in reduced misclassification of CKD. As of November 2009, very few clinical laboratories report the
estimated GFR using the CKD-EPI creatinine equation. In the future, other GFR estimating equations may outperform CKD-EPI.
The CKD-EPI creatinine equation is:
Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease
Epidemiology Collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate.
Ann Intern Med. 2006 Aug 15;145(4):247-54.
AACC - American Association of Clinical Chemistry Q & A with W. Gregory Miller, PhD, DABCC, FACB
G.L. Myers, W.G. Miller, J. Coresh, J. Fleming, N. Greenberg, T. Greene, T. Hostetter, A.S. Levey, M. Panteghini, M. Welch, and J.H. Eckfeldt.
Recommendations for improving serum creatinine measurement:
A report from the laboratory working group of the National Kidney Disease Education Program.
Clinical Chemistry 2006 52: 5-18.
Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, Rahman M, Deysher AE, Zhang YL, Schmid CH, Levey AS. Evaluation of the modification of diet in renal disease study equation in a large diverse population J Am Soc Nephrol. 2007 Sep; 18(10):2749-57
Madero M, Sarnak MJ, Stevens LA. Serum cystatin C as a marker of glomerular filtration rate Curr Opin Nephrol Hypertens. 2006 Nov;15(6):610-6