6 GFR Equations - Estimating GFR in the Elderly
(With SI Units)

4 variable MDRD Equation, CKD-EPI Equation, CKD-EPI Cystatin C Equation (2012) and CKD-EPI Cystatin C-Creatinine Equation (2012), BIS 1 and BIS 2 Equations (with SI Units)
using standardized serum creatinine, age, race, gender and cystatin C

programmed by Stephen Z. Fadem, M.D., FACP, FASN
and Brian Rosenthal

NOTE: CKD-EPI GFR is only valid with creatinine methods are traceable to IDMS
TRACEABLE TO IDMS(What is this?)

CKD-EPI Value: epi

CKD-EPI CYSTATIN Value: cystatin



BIS1 GFR: bis1

BIS2 GFR: bis2

(Age, Race, Gender, Plasma creatinine,Serum cystatin C)


*All ethnic groups other than African American
Shortcut: Type underlined letters to toggle between variables


  • Andrew S. Levey, MD; Lesley A. Stevens, MD, MS; Christopher H. Schmid, PhD; Yaping (Lucy) Zhang, MS; Alejandro F. Castro III, MPH; Harold I. Feldman, MD, MSCE; John W. Kusek, PhD; Paul Eggers, PhD; Frederick Van Lente, PhD; Tom Greene, PhD; and Josef Coresh, MD, PhD, MHS, for the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A New Equation to Estimate Glomerular Filtration Rate. Ann Intern Med. 2009 May 5;150(9):604-12

  • Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin. Chem, 2007 Apr;53(4):766-72. Epub 2007 Mar 1.

  • A more accurate accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group Ann Intern Med 1999 Mar 16; 130 (6): 461-70.

  • A.S. Levey, T. Greene, J.W. Kusek, G.L. Beck, MDRD Study Group. A simplified equation to predict glomerular filtration rate from serum creatinine (abstract) J Am Soc Nephrol 2000 Sep; 11:155A

  • Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006 Aug 15;145(4):247-54.

  • AACC - American Association of Clinical Chemistry Q & A with W. Gregory Miller, PhD, DABCC, FACB

  • G.L. Myers, W.G. Miller, J. Coresh, J. Fleming, N. Greenberg, T. Greene, T. Hostetter, A.S. Levey, M. Panteghini, M. Welch, and J.H. Eckfeldt. Recommendations for improving serum creatinine measurement: A report from the laboratory working group of the National Kidney Disease Education Program. Clinical Chemistry 2006 52: 5-18.

  • Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, Rahman M, Deysher AE, Zhang YL, Schmid CH, Levey AS. Evaluation of the modification of diet in renal disease study equation in a large diverse population J Am Soc Nephrol. 2007 Sep; 18(10):2749-57

  • Madero M, Sarnak MJ, Stevens LA. Serum cystatin C as a marker of glomerular filtration rate Curr Opin Nephrol Hypertens. 2006 Nov;15(6):610-6

  • Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators. Estimating glomerular filtration rate from serum creatinine and cystatin C. New Eng J Med 2012 Jul 5;367(1):20-9.

  • Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, Kuhlmann MK, Schuchardt M, Tölle M, Ziebig R, van der Giet M, Martus P. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012 Oct 2;157(7):471-81

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