GFR Calculators: Serum Creatinine and Cystatin C (thru 2021)
(With SI Units)

4 variable MDRD Study Equation, CKD-EPI Cystatin C Equation (eGFRcys2012), CKD-EPI Equation (eGFRcr2009), CKD-EPI Creatinine-Cystatin C Equation(eGFRcr-cys2012), CKD-EPI Creatinine NO RACE Equation (eGFRcr2021), and CKD-EPI Creatinine - Cystatin C NO RACE Equation (eGFRcr-cys2021) (with SI Units)
using standardized serum creatinine, age, race*, gender and serum cystatin C. Also includes body surface area (BSA), GFR Not corrected to BSA of 1.73m2, Cockcroft-Gault Formula, Total Body Water (TBW) (Watson), Body Mass Index (BMI), and the Tangri Kidney Failure prediction Model.

*The RACE variable is not necessary for equations of 2021. Please contact Dr. Fadem at fadem@bcm.edu if any errors or questions

programmed by Stephen Z. Fadem, M.D., FACP, FASN
and Brian Rosenthal



NOTE: CKD-EPI GFR is only valid with serum creatinine methods are traceable to IDMS
years
Race
Gender
alb/cr mg/grams
TRACEABLE TO IDMS(What is this?)
EQUATION:VALUE:
(mL/min/1.73 m2)
MDRD STUDY EQUATION: mdr
CKD-EPI CYSTATIN C (2012)cystatin
CKD-EPI CREATININE (2009) epi09
CKD-EPI CREATININE-CYSTATIN C (2012) cysepi12
CKD-EPI CREATININE-NO-RACE (2021) epi21
CKD-EPI CREATININE-CYSTATIN C-NO-RACE (2021) cysepi21
CYSTATIN C/CKD-EPI RATIO cys-epi ratio


MDRD STUDY EQ
CKD-EPI CYSTATIN C (2012)
CKD-EPI CREATININE EQ (2009)
CKD-EPI CREATININE-CYSTATIN C (2012)
CKD-EPI CREATININE EQ-NO-RACE (2021)
CKD-EPI CREATININE-CYSTATIN C-NO-RACE (2021)

*All ethnic groups other than African American
Shortcut: Type underlined letters to toggle between variables

As of January 2013, many large commercial clinical laboratories have changed from using the MDRD Study equation to the CKD-EPI Creatine 2009 Equation for eGFR reporting.


*O=non African American (non in 2021 Eq). Cr=creatinine. Cys=cystatin. Eq=Equation.
Another Version of the Kidney Failure Risk Equation
Body Mass Index (BMI), Cockcroft-Gault Estimated Creatinine Clearance (CG CCR, Total Body Water (TBW), Body Surface Area(BSA). Remove BSA adjustment to express GFR in ml/min. Tangri Values and Constants.


BMI, CG CCR, TBW, BSA, Remove BSA
to Express GFR in ml/min. Tangri values and constants
Height
feet inches centimeters
Weight
Enter and select
pounds kilograms
BODY SURFACE AREA (BSA):
TOTAL BODY WATER:
Height:height
Weight:weight
BODY MASS INDEX:
COCKCROFT GAULT CR CLEARANCE:
UNADJUSTED GFRGFR VALUE
MDRD STUDY EQUATION
CKD-EPI CREATININE EQ (2009)
CKD-EPI CYSTATIN C EQUATION (2012)
CKD-EPI CR-CYSTATIN C EQ (2012)
CKD-EPI CREATININE NO RACE EQ (2021)
CKD-EPI CR-CYSTATIN C NO RACE EQ (2021)
FORMULAE
BSA (m2) = (W0.425 x H 0.725) x 0.007184
Unadjusted CKD-EPI eGFR (ml/min) = eGFR (ml/min/1.73 m2) x BSA (m2) / 1.73
BMI= weight/height2
TANGRI EQUATION VALUES AND CONSTANTS:
JAMA 2016; 315 :164-74 & 822
Male=1 Female=0
beta
Tangri 5 yr Non NA Constant=0.9365
Tangri 2 yr Non NA Constant=0.9832
Tangri 5 yr NA Constant=0.9240
Tangri 2 yr NA Constant=0.9750
ADDITIONAL INFORMATION

Pediatric Calculator

MDRD STUDY EQUATION SI Default

Cockcroft-Gault Calculator

Cockcroft-Gault Calculator (defaults to SI Units)

Summary of the MDRD Study and
CKD-EPI Estimating Equations

KDIGO Classification of CKD

eGFR NOT adjusted for Body Surface Area

REFERENCES:


  • Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A New Equation to Estimate Glomerular Filtration Rate. Ann Intern Med. 2009 May 5;150(9):604-12.

  • Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration. Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem. 2007 Apr;53(4):766-72. Epub 2007 Mar 1. .

  • Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group Ann Intern Med. 1999 Mar 16;130(6):461-70.

  • Levey AS, Greene T, Kusek JW, Beck GL; MDRD Study Group. A simplified equation to predict glomerular filtration rate from serum creatinine (abstract) J Am Soc Nephrol 2000 Sep; 11:155A

  • Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006 Aug 15;145(4):247-54.

  • Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, Hostetter T, Levey AS, Panteghini M, Welch M, Eckfeldt JH; National Kidney Disease Education Program Laboratory Working Group; Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18.

  • Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, Rahman M, Deysher AE, Zhang YL, Schmid CH, Levey AS. Evaluation of the modification of diet in renal disease study equation in a large diverse population Madero M, Sarnak MJ, Stevens LA. Serum cystatin C as a marker of glomerular filtration rate Curr Opin Nephrol Hypertens. 2006 Nov;15(6):610-6

  • Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators. Estimating glomerular filtration rate from serum creatinine and cystatin C. New Eng J Med 2012 Jul 5;367(1):20-9.

  • Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, Kuhlmann MK, Schuchardt M, Tölle M, Ziebig R, van der Giet M, Martus P. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012 Oct 2;157(7):471-81

  • Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, et al. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race. N Engl J Med. 2021;385(19):1737-49

  • Inker LA, Eneanya ND, Coresh J, Tighiouart H, Wang D, Sang Y, et al. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race - Supplementary Appendix N Engl J Med. 2021;385(19):1737-49 Supplementary Appendix

    GFR PREDICTORS

  • Tangri N, Stevens LA, Griffith J, Tighiouart H, Djurdjev O, Naimark D, Levin A, Levey AS. A predictive model for progression of chronic kidney disease to kidney failure. JAMA. 2011 Apr 20;305(15):1553-9.

  • Tangri N, Grams ME, Levey AS, Coresh J, Appel LJ, Astor BC, Chodick G, Collins AJ, Djurdjev O, Elley CR, Evans M, Garg AX, Hallan SI, Inker LA, Ito S, Jee SH, Kovesdy CP, Kronenberg F, Heerspink HJ, Marks A, Nadkarni GN, Navaneethan SD, Nelson RG, Titze S, Sarnak MJ, Stengel B, Woodward M, Iseki K; CKD Prognosis Consortium. Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis.JAMA. 2016;315(2):164-74.

  • Tangri N, Grams ME, Levey AS, et al. Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis. Supplement JAMA. 2016;315(2):164-74.

      • LOW CYSTATIN C AND ATHEROSCLEROSIS

    • A low serum Cystatin C equates to a hi nystatin C GFR and a lower cys/epi GFR ratio

    • Sawed, S. Cystatin C as a Promising Biomarker of Atherosclerotic Plaque. J Atheroscler Thromb. 2020 Sep 10;28(5):474–476.



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